The ‘ins’ and ‘outs’ of flavonoid transport

The ins and outs of tRNA transport.

Transfer RNAs (tRNAs) are involved in many cellular functions distributed throughout the cellular space. In addition to their role in protein translation, these molecules are engaged in tasks as diverse as the regulation of gene expression, amino-acid synthesis, protein degradation, cell-wall synthesis, porphyrin bio synthesis, priming of replication, RNA interference and the transport of macro...

Protein transport: The nonclassical ins and outs

Recent evidence that a herpes virus protein lacking a classical secretory signal sequence can spread between cells in culture draws attention to a class of proteins that are transported into and out of cells by unconventional means.

Ins and outs of cellular cobalamin transport.

Plant Cell Polarity: The Ins-and-Outs of Sterol Transport

A colleague introduces his lectures on the ability of plants to adapt to their environment with a photograph of a polar bear on the frozen tundra. The image is taken from a popular natural history publication which eulogises the ability of mammals to colonise diverse hostile environments — but the reason for showing this photograph is of course to point out the underlying vegetation which suppo...

The ins and outs of erythroid heme transport.

Heme plays critical roles in erythropoiesis not only as a structural component of hemoglobin but also as a regulator of erythroid proliferation by affecting the expression of proteins involved in iron transport and globin synthesis. Within the cell, heme is synthesized in the mitochondria and is subsequently transported to the cytosol for incorporation into hemoglobin and other hemoproteins. Be...